Immunotherapy of Melanoma: Facts and Hopes

Genetic markers of osteoarticular disorders: facts and hopes

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inver...

Allergen immunotherapy: the scientific facts.

Melanoma Genomics and Immunotherapy.

Over the last decade the molecular characterization of melanoma has progressed. Since a majority of melanoma cases arise from repeated intermittent ultra violet radiation (UVR) exposure, the role of UVR has been evaluated extensively. Recent work has identified two mechanisms in which the carcinogenesis of melanoma may result; Ultra violet radiation has been demonstrated to lead to down regulat...

Melanoma immunotherapy

Cutaneous malignant melanoma is amongst the most aggressive cancer types, which typifies the paradox of being simultaneously highly antigenic and highly immunoevasive [1, 2]. However, various anti-melanoma immunotherapies have shown limited clinical success e.g. IL2, IFN-α2a or dendritic cells (DCs)-based vaccines [1-3]. Subsequent research showed that tumor-induced immunosuppression caused fai...

Sublingual immunotherapy in children: facts and needs

Allergen specific immunotherapy (SIT) is the practice of administering gradually increasing doses of the specific causative allergen to reduce the clinical reactivity of allergic subjects, and is the only treatment targeting the causes of hypersensitivity and not only the symptoms, as done by drugs. The traditional, subcutaneous immunotherapy (SCIT) was burdened by the problem of systemic react...